John or Jack Keller may refer to:

• John Keller (basketball) (1928–2000), basketball player
• John Keller (boxer), (1910-1980), American Olympic boxer
• John Keller (handballer), (born 1965), American Olympic handballer
• Jack Keller (athlete) (1911–1978), American Olympic hurdler
• Jack Keller (artist) (1922–2003), Marvel Comics artist
• Jack Keller (poker player) (1942–2003), American poker player
• Jack Keller (songwriter) (1936–2005), American composer, songwriter and record producer

• Johnny Keller, murder victim