Hystrix may refer to:

• Ichthyosis hystrix, a class of rare skin disorder characterized by massive hyperkeratosis with an appearance like spiny scales

• Hystrix (diatom) Bory de Saint-Vincent 1822, a diatom genus
• Hystrix (plant) Moench 1794, a plant genus in the family Poaceae
• Hystrix (mammal), a rodent genus

• a library to implement the bulkhead pattern from Netflix, see Hystrix