Protein-coding gene in the species Homo sapiens
Hippocalcin is a protein that in humans is encoded by the HPCA gene .[ 5] [ 6]
Hippocalcin is a calcium -binding protein that belongs to the neuronal calcium sensor (NCS) family of proteins.[ 7] [ 8] mammalian brains especially in the hippocampus . It possesses a Ca2+ /myristoyl switch.[ 9]
Processes Hippocalcin takes part in the following processes:
Interactions Hippocalcin interacts with following proteins:
Neuronal apoptosis inhibitory protein (NAIP )
Mixed lineage kinase 2 (MLK2 ) – MLK2 is myosin light chain kinase 2
The b2 adaptin of the AP2 complex
Calcium-dependent activator protein for secretion (CADPS )
References
^ a b c GRCh38: Ensembl release 89: ENSG00000121905 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028785 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Takamatsu K, Kobayashi M, Saitoh S, Fujishiro M, Noguchi T (April 1994). "Molecular cloning of human hippocalcin cDNA and chromosomal mapping of its gene". Biochem. Biophys. Res. Commun . 200 (1): 606–11. doi :10.1006/bbrc.1994.1491 . PMID 8166736 . ^ Masaki T, Sakai E, Furuta Y, Kobayashi M, Takamatsu K (December 1998). "Genomic structure and chromosomal mapping of the human and mouse hippocalcin genes". Gene . 225 (1–2): 117–24. doi :10.1016/S0378-1119(98)00526-5 . PMID 9931466 . ^ Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling" . Nat. Rev. Neurosci . 8 (3): 182–193. doi :10.1038/nrn2093 . PMC 1887812 PMID 17311005 . ^ Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci . 27 (4): 203–9. doi :10.1016/j.tins.2004.01.010 . PMID 15046879 . S2CID 24156457 . ^ O'Callaghan DW, Tepikin AV, Burgoyne RD (2003). "Dynamics and calcium sensitivity of the Ca2+/myristoyl switch protein hippocalcin in living cells" . J. Cell Biol . 163 (4): 715–721. doi :10.1083/jcb.200306042 . PMC 2173692 PMID 14638856 .
Further reading
Hidaka H, Okazaki K (1993). "Neurocalcin family: a novel calcium-binding protein abundant in bovine central nervous system". Neurosci. Res . 16 (2): 73–7. doi :10.1016/0168-0102(93)90074-Z . PMID 8387172 . S2CID 4210072 . Nagao M, Hayashi H (2009). "Mixed lineage kinase 2 and hippocalcin are localized in Lewy bodies of Parkinson's disease". J. Neurol. Sci . 281 (1–2): 51–4. doi :10.1016/j.jns.2009.02.375 . PMID 19332348 . S2CID 13177773 . Kobayashi M, Takamatsu K, Saitoh S, et al. (1992). "Molecular cloning of hippocalcin, a novel calcium-binding protein of the recoverin family exclusively expressed in hippocampus". Biochem. Biophys. Res. Commun . 189 (1): 511–7. doi :10.1016/0006-291X(92)91587-G . PMID 1280427 . Nagata K, Puls A, Futter C, et al. (1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3" . EMBO J . 17 (1): 149–58. doi :10.1093/emboj/17.1.149 . PMC 1170366 PMID 9427749 . Kobayashi M, Takamatsu K, Saitoh S, Noguchi T (1993). "Myristoylation of hippocalcin is linked to its calcium-dependent membrane association properties" . J. Biol. Chem . 268 (25): 18898–904. doi :10.1016/S0021-9258(17)46711-1 PMID 8360179 . Rudinskiy N, Kaneko YA, Beesen AA, et al. (2009). "Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons" . J. Neurochem . 111 (2): 460–72. doi :10.1111/j.1471-4159.2009.06344.x PMID 19686238 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Mercer EA, Korhonen L, Skoglösa Y, et al. (2000). "NAIP interacts with hippocalcin and protects neurons against calcium-induced cell death through caspase-3-dependent and -independent pathways" . EMBO J . 19 (14): 3597–607. doi :10.1093/emboj/19.14.3597 . PMC 313967 PMID 10899114 . Ivings L, Pennington SR, Jenkins R, et al. (2002). "Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin" . Biochem. J . 363 (Pt 3): 599–608. doi :10.1042/0264-6021:3630599 . PMC 1222513 PMID 11964161 . O'Callaghan DW, Haynes LP, Burgoyne RD (2005). "High-affinity interaction of the N-terminal myristoylation motif of the neuronal calcium sensor protein hippocalcin with phosphatidylinositol 4,5-bisphosphate" . Biochem. J . 391 (Pt 2): 231–8. doi :10.1042/BJ20051001 . PMC 1276920 PMID 16053445 . O'Callaghan DW, Ivings L, Weiss JL, et al. (2002). "Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2+ signal transduction" . J. Biol. Chem . 277 (16): 14227–37. doi :10.1074/jbc.M111750200 PMID 11836243 . Markova 0, Fitzgerald D, Stepanyuk A; et al. (2009). "Hippocalcin signaling via site-specific translocation in hippocampal neurons" . Neurosci. Lett . 442 (2): 152–7. doi :10.1016/j.neulet.2008.06.089 . PMC 2572729 PMID 18634855 . {{cite journal }}: CS1 maint: multiple names: authors list (link ) CS1 maint: numeric names: authors list (link )
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