Heartthrob or Heart Throb may refer to:

• "Heart Throb" (The Super Mario Bros. Super Show!), a live-action episode of The Super Mario Bros. Super Show!
• "Heartthrob" (Angel), an episode of the American television show Angel
• Heartthrob (album), studio album by Tegan and Sara
• Heartthrob (film), a 2017 American thriller film
• Heart Throb (My Little Pony), a Pegasus pony in the My Little Pony franchise
• Heart Throbs, a romance comic published by Quality Comics and DC Comics
• The Heart Throbs, an American professional wrestling tag team
• The Heart Throbs (band), a British indie-rock band