Six Royal Navy ships have borne the name HMS Southampton. All were named after Southampton, a port on the south coast of England.

• HMS Southampton (1693) was a 48-gun fourth rate launched in 1693. The ship was rebuilt in 1700, hulked at Jamaica in 1728 and finally broken up in 1771.
• HMS Southampton (1757) was a 32-gun fifth rate launched in 1757, and wrecked in 1812.
• HMS Southampton (1820) was a 60-gun fourth rate launched in 1820. In 1867 the ship was lent to the Hull Committee, finally being sold in 1912.
• HMS Southampton (1912) was a Town-class cruiser, launched in 1912 and sold in 1926. She fought at the Battle of Jutland.
• HMS Southampton (C83) was a Town-class cruiser, launched in 1936 and sunk off Malta on 11 January 1941.
• HMS Southampton (D90) was a Type 42 destroyer, launched in 1979 and decommissioned in 2009.

• Emeraude 1757
• Belle Isle 1761
• The Glorious First of June 1794
• St Vincent 1797
• Heligoland 1914
• Dogger Bank 1915
• Jutland 1916
• Norway 1940
• Spartivento 1940
• Malta Convoys 1941

• Colledge, J. J.; Warlow, Ben (2006) [1969]. Ships of the Royal Navy: The Complete Record of all Fighting Ships of the Royal Navy (Rev. ed.). London: Chatham Publishing. ISBN 978-1-86176-281-8.
• Gossett, William Patrick (1986) The lost ships of the Royal Navy, 1793-1900. (London: Mansell). ISBN 0-7201-1816-6