Protein-coding gene in the species Homo sapiens
Hypermethylated in cancer 1 protein is a protein that in humans is encoded by the HIC1 gene .[ 5]
References
Further reading
Chopin V, Leprince D (2006). "[Chromosome arm 17p13.3: could HIC1 be the one ?]" . Med Sci (Paris) . 22 (1): 54– 61. doi :10.1051/medsci/200622154 PMID 16386221 . Wales MM, Biel MA, el Deiry W, et al. (1995). "p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3". Nat. Med . 1 (6): 570– 7. doi :10.1038/nm0695-570 . PMID 7585125 . S2CID 21993943 . Fujii H, Biel MA, Zhou W, et al. (1998). "Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer" . Oncogene . 16 (16): 2159– 64. doi :10.1038/sj.onc.1201976 PMID 9572497 . Deltour S, Guerardel C, Stehelin D, Leprince D (1999). "The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved". Biochim. Biophys. Acta . 1443 (1– 2): 230– 2. doi :10.1016/s0167-4781(98)00219-x . PMID 9838134 . Deltour S, Guerardel C, Leprince D (2000). "Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B" . Proc. Natl. Acad. Sci. U.S.A . 96 (26): 14831– 6. Bibcode :1999PNAS...9614831D . doi :10.1073/pnas.96.26.14831 PMC 24733 PMID 10611298 . Guerardel C, Deltour S, Pinte S, et al. (2001). "Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53" . J. Biol. Chem . 276 (5): 3078– 89. doi :10.1074/jbc.M008690200 PMID 11073960 . Deltour S, Pinte S, Guérardel C, Leprince D (2001). "Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1". Biochem. Biophys. Res. Commun . 287 (2): 427– 34. doi :10.1006/bbrc.2001.5624 . PMID 11554746 . Deltour S, Pinte S, Guerardel C, et al. (2002). "The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif" . Mol. Cell. Biol . 22 (13): 4890– 901. doi :10.1128/MCB.22.13.4890-4901.2002 . PMC 133903 PMID 12052894 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Cardoso C, Leventer RJ, Ward HL, et al. (2003). "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3" . Am. J. Hum. Genet . 72 (4): 918– 30. doi :10.1086/374320 . PMC 1180354 PMID 12621583 . Rathi A, Virmani AK, Harada K, et al. (2004). "Aberrant methylation of the HIC1 promoter is a frequent event in specific pediatric neoplasms". Clin. Cancer Res . 9 (10 Pt 1): 3674– 8. PMID 14506157 . Waha A, Waha A, Koch A, et al. (2004). "Epigenetic silencing of the HIC-1 gene in human medulloblastomas" . J. Neuropathol. Exp. Neurol . 62 (11): 1192– 201. doi :10.1093/jnen/62.11.1192 PMID 14656076 . Lindsey JC, Lusher ME, Anderton JA, et al. (2004). "Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling" . Carcinogenesis . 25 (5): 661– 8. doi :10.1093/carcin/bgh055 PMID 14688019 . Pinte S, Guérardel C, Deltour-Balerdi S, et al. (2004). "Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1" . Oncogene . 23 (22): 4023– 31. doi :10.1038/sj.onc.1207504 PMID 15007385 . Pinte S, Stankovic-Valentin N, Deltour S, et al. (2004). "The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties" . J. Biol. Chem . 279 (37): 38313– 24. doi :10.1074/jbc.M401610200 PMID 15231840 . Chen W, Cooper TK, Zahnow CA, et al. (2004). "Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis" . Cancer Cell . 6 (4): 387– 98. doi :10.1016/j.ccr.2004.08.030 PMID 15488761 . Britschgi C, Rizzi M, Grob TJ, et al. (2006). "Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1". Oncogene . 25 (14): 2030– 9. doi :10.1038/sj.onc.1209240 . PMID 16301995 . S2CID 27624320 . Valenta T, Lukas J, Doubravska L, et al. (2006). "HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies" . EMBO J . 25 (11): 2326– 37. doi :10.1038/sj.emboj.7601147 . PMC 1478201 PMID 16724116 . Stankovic-Valentin N, Verger A, Deltour-Balerdi S, et al. (2006). "A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP". FEBS J . 273 (13): 2879– 90. doi :10.1111/j.1742-4658.2006.05301.x . PMID 16762039 . S2CID 34249691 .
External links
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
