Protein-coding gene in the species Homo sapiens
Hepatitis B virus X-interacting protein is a protein that in humans is encoded by the HBXIP gene .[ 5] [ 6]
This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus.[ 6]
Interactions HBXIP has been shown to interact with NCOA6 .[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000134248 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000087260 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Melegari M, Scaglioni PP, Wands JR (March 1998). "Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication" . Journal of Virology . 72 (3): 1737– 43. doi :10.1128/jvi.72.3.1737-1743.1998 . PMC 109461 PMID 9499022 . ^ a b "Entrez Gene: HBXIP hepatitis B virus x interacting protein" .^ Kong HJ, Park MJ, Hong S, Yu HJ, Lee YC, Choi YH, Cheong J (November 2003). "Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2" . Hepatology . 38 (5): 1258– 66. doi :10.1053/jhep.2003.50451 PMID 14578865 .
Further reading
Shamay M, Barak O, Doitsh G, Ben-Dor I, Shaul Y (March 2002). "Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription" . The Journal of Biological Chemistry . 277 (12): 9982– 8. doi :10.1074/jbc.M111354200 PMID 11788598 . Li Y, Lu YY (April 2002). "Applying a highly specific and reproducible cDNA RDA method to clone garlic up-regulated genes in human gastric cancer cells" . World Journal of Gastroenterology . 8 (2): 213– 6. doi :10.3748/wjg.v8.i2.213 PMC 4658353 PMID 11925594 . Marusawa H, Matsuzawa S, Welsh K, Zou H, Armstrong R, Tamm I, Reed JC (June 2003). "HBXIP functions as a cofactor of survivin in apoptosis suppression" . The EMBO Journal . 22 (11): 2729– 40. doi :10.1093/emboj/cdg263 . PMC 156760 PMID 12773388 . Kong HJ, Park MJ, Hong S, Yu HJ, Lee YC, Choi YH, Cheong J (November 2003). "Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2" . Hepatology . 38 (5): 1258– 66. doi :10.1053/jhep.2003.50451 PMID 14578865 . Lee SH, Park SG, Lim SO, Jung G (June 2005). "The hepatitis B virus X protein up-regulates lymphotoxin alpha expression in hepatocytes" . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease . 1741 (1– 2): 75– 84. doi :10.1016/j.bbadis.2004.10.004 PMID 15955450 . Lee AT, Ren J, Wong ET, Ban KH, Lee LA, Lee CG (September 2005). "The hepatitis B virus X protein sensitizes HepG2 cells to UV light-induced DNA damage" . The Journal of Biological Chemistry . 280 (39): 33525– 35. doi :10.1074/jbc.M506628200 PMID 16055925 . Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell . 122 (6): 957– 68. doi :10.1016/j.cell.2005.08.029 . hdl :11858/00-001M-0000-0010-8592-0 PMID 16169070 . S2CID 8235923 . Minczuk M, Mroczek S, Pawlak SD, Stepien PP (October 2005). "Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP" . The FEBS Journal . 272 (19): 5008– 19. doi :10.1111/j.1742-4658.2005.04910.x PMID 16176273 . S2CID 40846992 . Muroyama R, Kato N, Yoshida H, Otsuka M, Moriyama M, Wang Y, Shao RX, Dharel N, Tanaka Y, Ohta M, Tateishi R, Shiina S, Tatsukawa M, Fukai K, Imazeki F, Yokosuka O, Shiratori Y, Omata M (December 2006). "Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma" . Journal of Hepatology . 45 (6): 805– 12. doi :10.1016/j.jhep.2006.07.025 . PMID 17050029 . Chen J, Siddiqui A (June 2007). "Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress" . Journal of Virology . 81 (12): 6757– 60. doi :10.1128/JVI.00172-07 . PMC 1900104 PMID 17428866 .
