Gozzadini is a surname. Notable people with the surname include:

• Angelo I Gozzadini (died between 1468 and 1476), Lord of Kythnos
• Angelo Gozzadini (1573–1653), Roman Catholic prelate
• Bettisia Gozzadini (1209–1261), Italian jurist
• Francesco Gozzadini (died 1673), Roman Catholic prelate
• Giovanni Gozzadini (1810–1887), Italian archaeologist
• Marcantonio Gozzadini (1574–1623), Italian cardinal, cousin of Pope Gregory XV
• Maria Teresa Gozzadini (1812–1881), Italian geologist and countess
• Tommaso Gozzadini (1260–after 1329), Italian notary
• Ulisse Giuseppe Gozzadini (1650–1728), Italian cardinal and bishop of Imola