Gonzalo Rodríguez may refer to:

• Gonzalo Rodríguez (athlete), Mexican sprinter
• Gonzalo Rodríguez (footballer, born 1984), Argentine footballer
• Gonzalo Rodríguez (footballer, born 1987), Argentine footballer
• Gonzalo Rodríguez (footballer, born 1990), Argentine footballer
• Gonzalo Rodríguez (footballer, born 1991), Spanish footballer
• Gonzalo Rodríguez (footballer, born 1997), Argentine footballer
• Gonzalo Rodríguez (racing driver) (1971–1999), racing driver
• Gonzalo Rodríguez Anaya (born 1942), Mexican politician
• Gonzalo Rodríguez de las Varillas (1270–1345), Spanish nobleman
• Gonzalo Rodríguez Girón (c. 1160–1231), one of Castile's wealthiest and most powerful nobles
• Gonzalo Rodríguez Lafora (1886–1971), Spanish neurologist
• Gonzalo Rodriguez-Pereyra (born 1969), Argentine philosopher
• Gonzalo Rodríguez Risco (born 1972), Peruvian playwright and screenwriter
• José Gonzalo Rodríguez Gacha (1947–1989), Colombian drug lord
• Gonzalo Ruiz (died 1205), also known as Gonzalo Rodríguez, former ruler of La Bureba in Spain