George Middleton may refer to:

• George Middleton (activist) (1735–1815), African-American Revolutionary War veteran, activist, and Freemason
• George Augustus Middleton (1791–1848), English-Australian pastor and farmer
• George Middleton (American politician) (1800–1888), New Jersey congressman
• George H. Middleton (died 1892), Scottish engineer
• George "Bay" Middleton (1846–1892), British equestrian
• Sir George Middleton (British politician) (1876–1938), Labour member of parliament for Carlisle 1922–1924, 1929–1931
• George E. Middleton, American film director and producer
• George Middleton (playwright) (1880–1967), American playwright, director, and producer
• George Middleton (trade unionist) (1898–1971), general secretary of the Scottish Trades Union Congress
• Sir George Middleton (diplomat) (1910–1998), British diplomat