Game of Bones may refer to:

• Bunnock, a Russian game involving horse anklebones
• Dominoes, in which the pieces are called bones
• Dice games, in which the dice are called bones
• A Game of Bones, novel by David Donachie, part of The Privateersman Mysteries series
• "Game of Bones", an episode of the reality television cooking competition Kitchen Casino
• "Game of Bones", an episode of the children's television series Mutt & Stuff
• Game of Bones: Winter Is Cumming, a pornographic film parody by Lee Roy Myers

• Bone (disambiguation)
• Knucklebones, a.k.a. jacks