Putative gonadotropin-releasing hormone II receptor is a protein that in humans is encoded by the GNRHR2gene.[3][4]
Function
The receptor for gonadotropin-releasing hormone 2 (GnRH2) is encoded by the GnRH2 receptor (GnRHR2) gene. In non-hominoid primates and non-mammalian vertebrates, GnRHR2 encodes a seven-transmembrane G protein-coupled receptor. However, in humans, the N-terminus of the predicted protein contains a frameshift and premature stop codon. In humans, GnRHR2 transcription occurs but whether the gene produces a functional C-terminal multi-transmembrane protein is currently unresolved. Alternative splice variants have been reported. An untranscribed pseudogene of GnRHR2 is also on chromosome 14.[4]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Faurholm B, Millar RP, Katz AA (Nov 2001). "The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci". Genomics. 78 (1–2): 15–8. doi:10.1006/geno.2001.6650. PMID11707068.
Eicke N, Günthert AR, Viereck V, et al. (2005). "GnRH-II receptor-like antigenicity in human placenta and in cancers of the human reproductive organs". Eur. J. Endocrinol. 153 (4): 605–12. doi:10.1530/eje.1.02005. PMID16189182.
