GCM2

GCM2
Identifiers
Aliases	GCM2, GCMB, hGCMb, glial cells missing homolog 2, HRPT4, glial cells missing transcription factor 2, FIH2
External IDs	OMIM: 603716; MGI: 1861438; HomoloGene: 3490; GeneCards: GCM2; OMA:GCM2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	10,882,041 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	41,264,511 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	9247
	107889
	ENSG00000124827
	ENSMUSG00000021362
	O75603
	O09102
	NM_004752
	NM_008104
	NP_004743
	NP_032130
	Wikidata
View/Edit Human	View/Edit Mouse

Chorion-specific transcription factor GCMb is a protein that in humans is encoded by the GCM2 gene.^[5]^[6]

The Drosophila 'glial cells missing' (gcm) gene is thought to act as a binary switch between neuronal and glial cell determination. The gcm protein and mammalian gcm homologs contain a conserved N-terminal gcm motif that has DNA-binding activity. See GCM1 (MIM 603715).[supplied by OMIM]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124827 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021362 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kanemura Y, Hiraga S, Arita N, Ohnishi T, Izumoto S, Mori K, Matsumura H, Yamasaki M, Fushiki S, Yoshimine T (Feb 1999). "Isolation and expression analysis of a novel human homologue of the Drosophila glial cells missing (gcm) gene". FEBS Lett. 442 (2–3): 151–6. doi:10.1016/S0014-5793(98)01650-0. PMID 9928992. S2CID 2469563.
^ ^a ^b "Entrez Gene: GCM2 glial cells missing homolog 2 (Drosophila)".

Kammerer M, Pirola B, Giglio S, Giangrande A (1999). "GCMB, a second human homolog of the fly glide/gcm gene". Cytogenet. Cell Genet. 84 (1–2): 43–7. doi:10.1159/000015210. PMID 10343099. S2CID 23760189.
Correa P, Akerström G, Westin G (2002). "Underexpression of Gcm2, a master regulatory gene of parathyroid gland development, in adenomas of primary hyperparathyroidism". Clin. Endocrinol. 57 (4): 501–5. doi:10.1046/j.1365-2265.2002.01627.x. PMID 12354132. S2CID 2137270.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Maret A, Bourdeau I, Ding C, et al. (2004). "Expression of GCMB by intrathymic parathyroid hormone-secreting adenomas indicates their parathyroid cell origin". J. Clin. Endocrinol. Metab. 89 (1): 8–12. doi:10.1210/jc.2003-030733. PMID 14715818.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kebebew E, Peng M, Wong MG, et al. (2005). "GCMB gene, a master regulator of parathyroid gland development, expression, and regulation in hyperparathyroidism". Surgery. 136 (6): 1261–6. doi:10.1016/j.surg.2004.06.056. PMID 15657585.
Thomée C, Schubert SW, Parma J, et al. (2005). "GCMB mutation in familial isolated hypoparathyroidism with residual secretion of parathyroid hormone". J. Clin. Endocrinol. Metab. 90 (5): 2487–92. doi:10.1210/jc.2004-2450. PMID 15728199.
Baumber L, Tufarelli C, Patel S, et al. (2006). "Identification of a novel mutation disrupting the DNA binding activity of GCM2 in autosomal recessive familial isolated hypoparathyroidism". J. Med. Genet. 42 (5): 443–8. doi:10.1136/jmg.2004.026898. PMC 1736051. PMID 15863676.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124827 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021362 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9928992-5] Kanemura Y, Hiraga S, Arita N, Ohnishi T, Izumoto S, Mori K, Matsumura H, Yamasaki M, Fushiki S, Yoshimine T (Feb 1999). "Isolation and expression analysis of a novel human homologue of the Drosophila glial cells missing (gcm) gene". FEBS Lett. 442 (2–3): 151–6. doi:10.1016/S0014-5793(98)01650-0. PMID 9928992. S2CID 2469563.

[entrez-6] "Entrez Gene: GCM2 glial cells missing homolog 2 (Drosophila)".

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Fahrer / Team für die Suche eingeben:

Fahrer / Team für die Suche eingeben:

Langbahn Team – Weltmeisterschaft

GCM2

References

Further reading