Protein-coding gene in humans
Gamma-aminobutyric acid receptor subunit theta is a protein that in humans is encoded by the GABRQ gene .[ 5] [ 6] protein encoded by this gene is a subunit of the GABAA receptor .
The θ subunit has highest sequence similarity with the β1 subunit.[ 6]
α2, β1, and γ1[ 6]
α3 and β1[ 7]
α3, β1, and ε.[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000268089 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031344 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Sinkkonen ST, Hanna MC, Kirkness EF, Korpi ER (15 May 2000). "GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus" . J. Neurosci . 20 (10): 3588–3595. doi :10.1523/jneurosci.20-10-03588.2000 PMC 6772669 PMID 10804200 . ^ a b c Bonnert TP, McKernan RM, Farrar S, le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Brown N, Wafford KA, Whiting PJ (August 1999). "θ, a novel γ-aminobutyric acid type A receptor subunit" . Proc. Natl. Acad. Sci. U.S.A . 96 (17): 9891–9896. Bibcode :1999PNAS...96.9891B . doi :10.1073/pnas.96.17.9891 PMC 22306 PMID 10449790 . ^ a b Ranna M, Sinkkonen ST, Möykkynen T, Uusi-Oukari M, Korpi ER (2006). "Impact of ε and θ subunits on pharmacological properties of α3β1 GABAA receptors expressed in Xenopus oocytes" . BMC Pharmacol . 6 : 1. doi :10.1186/1471-2210-6-1 PMC 1363348 PMID 16412217 .
Further reading
Whiting PJ, Bonnert TP, McKernan RM, et al. (1999). "Molecular and functional diversity of the expanding GABA-A receptor gene family". Ann. N. Y. Acad. Sci . 868 (1): 645–653. Bibcode :1999NYASA.868..645W . doi :10.1111/j.1749-6632.1999.tb11341.x . PMID 10414349 . S2CID 13130259 . Craddock N, Jones L, Jones IR, et al. (2010). "Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype" . Mol. Psychiatry . 15 (2): 146–153. doi :10.1038/mp.2008.66 . PMC 3967096 PMID 19078961 . Sinkkonen ST, Hanna MC, Kirkness EF, Korpi ER (2000). "GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus" . J. Neurosci . 20 (10): 3588–3595. doi :10.1523/jneurosci.20-10-03588.2000 PMC 6772669 PMID 10804200 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–2127. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment" . Am. J. Med. Genet. B Neuropsychiatr. Genet . 150B (6): 808–816. doi :10.1002/ajmg.b.30902 PMID 19086053 . Bonnert TP, McKernan RM, Farrar S, et al. (1999). "θ, a novel γ-aminobutyric acid type A receptor subunit" . Proc. Natl. Acad. Sci. U.S.A . 96 (17): 9891–9896. Bibcode :1999PNAS...96.9891B . doi :10.1073/pnas.96.17.9891 PMC 22306 PMID 10449790 . Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–16903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Fernandez F, Esposito T, Lea RA, et al. (2008). "Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility" . BMC Med. Genet . 9 : 109. doi :10.1186/1471-2350-9-109 PMC 2615754 PMID 19087248 . Tabakoff B, Saba L, Printz M, et al. (2009). "Genetical genomic determinants of alcohol consumption in rats and humans" . BMC Biol . 7 : 70. doi :10.1186/1741-7007-7-70 PMC 2777866 PMID 19874574 .
External links
