Frederick or Fred Hughes may refer to:

• Frederick Hughes (1816–1889) of the Hughes baronets
• Frederick Hughes (footballer) (1860–?), Welsh footballer
• Frederick Hughes (sailor) (1866–1956), British Olympic sailor
• Frederick Llewelyn Hughes (1894–1967), Anglican priest and British Army chaplain
• Frederick W. Hughes (1943–2001), manager and executor of Andy Warhol
• Fred Hughes (rugby), 1940s Welsh rugby league footballer
• Fred Hughes (singer), 1960s American R&B singer
• Fred G. Hughes (1837–1911), American miner, gambler, and politician
• Fred G. Hughes (newspaper publisher) (1915–1996), American newspaper publisher and FBI agent
• F. W. Hughes (Fred William Hughes, 1869–1950), Australian businessman

• Frederic Hughes (1858–1944), Australian World War I general