Dr. Frasier Crane, formerly of Boston, has recently arrived back in his birthplace of Seattle to restart his life following his painful divorce. His independence is soon compromised by the fact that his father, Martin, is incapable of living by himself and must move into Frasier's apartment.

Guest Callers: Linda Hamilton as Claire; Griffin Dunne as Russell; John Mahoney as Martin (using his first name as a cover to thank Frasier)

After Martin moves into Frasier’s apartment with his physical therapist, Daphne, and his dog, Eddie, Frasier struggles with the loss of his personal space and ensuing tensions with Martin. After repeatedly failing to get any kind of solitary time at home or work, he decides to try forging a bond with his gruff father.

Guest Caller: Christopher Reeve as Leonard

Frasier and his brother, Niles, decide to treat Martin to a meal at fancy restaurant Le Cigare Volant in an attempt to improve his sense of style. Meanwhile, Niles meets Daphne for the first time and is instantly smitten, despite already being married.

Guest Caller: Patti LuPone as Pam

After being insulted on Frasier's show for a bad review, newspaper columnist Derek Mann challenges Frasier to a fistfight. Although Frasier agrees in the heat of the moment, Martin is angry to later learn he has no intention of going through with it. After learning of the shame he put Martin through when he ducked out of a similar situation as a child, Frasier resolves to meet the challenge.

Guest Callers: Joe Mantegna as Derek Mann; Judith Ivey as Lorraine

Frasier buys Martin a telescope as a gift. While looking through it, Martin spots a woman with whom he becomes romantically involved.

Guest Caller: Jeff Daniels as Doug

Frasier throws a cocktail party to show off a new painting he has bought, but is humiliated by the artist, who declares it is a forgery. When Frasier's attempts to return the painting to the gallery fail, he plots revenge against the gallery owner.

Guest Caller: Robert Klein as Gary

Frasier gives advice to a caller, Marco, to break off his relationship with his girlfriend, Catherine (Amanda Donohoe), because of his inability to commit. Niles questions Frasier's ethics when he ends up going on a date with Catherine.

Guest Callers: Bruno Kirby as Marco; Eddie Van Halen as Hank

After accidentally seeing Martin having an emotional meeting with an old family friend at a restaurant, Frasier and Niles begin to wonder whether Martin had an affair while married.

Guest Caller: JoBeth Williams as Danielle

Frasier meets Bebe Glazer (Harriet Sansom Harris), a smarmy talent agent who sweet-talks him into doing a series of product endorsements. He finds himself conflicted when she arranges a television ad for a product he does not support, knowing that the money earned could go toward his son's college fund.

Guest Caller: Carl Reiner as Roger

Frasier is told a rumor that one of the KACL on-air staff is getting fired. When sportscaster Bob 'Bulldog' Briscoe is called into a meeting with management, Frasier assumes the rumor is true and accidentally reveals it to him. As a result, Bulldog quits the station while Frasier learns that his job was actually safe. Feeling guilty and feeling pressure from Martin, Frasier decides to go to the station manager and beg for Bulldog's job back, only to learn the rumor was true and it was actually Frasier who was about to be fired.

Guest Caller: Jay Leno as Don

After the premature death of Martin's physician, who was similar to Frasier in physique, behavior and temperament, Frasier begins to obsess about his own mortality. Putting his affairs in order, he becomes determined to find more about the physician to the point he decides to attend his shiva.

Frasier's plans for Christmas with Frederick, Martin and Niles are derailed after Lilith decides to take Frederick to Austria. Already angry, Frasier then has a bitter argument with Martin, and agrees to do the Christmas Day shift at the radio station, which proves depressing.

Guest Callers: Mel Brooks as Tom; Rosemary Clooney as Gladys; Dominick Dunne as Jeff; Ben Stiller as Barry; Eric Stoltz as Don

Frasier is surprised to learn that Martin has been sleeping with a woman from his building. He then broadcasts this fact in his next show, embarrassing the woman and infuriating Martin. Feeling guilty, Frasier resolves to get them back together. Roz is going out with Noel Shempsky, a Star Trek addict.

Guest Callers: Piper Laurie as Marianne; Henry Mancini as Al; Elijah Wood as Ethan

Frasier takes part in a bachelor auction, where he is "bought" by Kristina Harper (Claire Stansfield), a model. He invites her for dinner at his apartment, but when she arrives, Kristina announces that she has some urgent business and needs Frasier to look after her daughter, Renata (Ashley Bank). Frasier learns from Renata that her mother is neglectful, leading him to criticize Kristina heavily when she returns, only to discover that Renata had invented the bad behavior she described.

After Roz is scammed by a street con, Frasier claims to always be able to spot a criminal, so Martin challenges him to a test: several of his friends will come over to play cards, including one ex-convict. Frasier wins if he can spot the con.

Lilith (Bebe Neuwirth) visits Frasier in Seattle, wondering if there's any chance of reconciliation after she finds a letter from him.

Guest Caller: Timothy Leary as Hank

After Niles has a fight with Maris, he and Daphne have a moment of mutual attraction during an attempt to make a reconciliation dinner. Daphne is stranded at Niles' mansion during a storm, and Frasier must reach them before they do something they both will regret.

Frasier discovers that he has been nominated for a local broadcasting award, and becomes obsessed with winning it.

Frasier is tired of Martin's favorite chair and replaces it, but Martin demands his old chair back. The old chair is easily located on the set of a school production, but the recovery proves more difficult.

Guest Caller: Malcolm McDowell as Dr. Bruga

Worrying about impending middle age, Frasier strikes up a tentative romance with a shop assistant several years his junior.

Guest Caller: Reba McEntire as Rachel

Frasier, Martin, Niles and Daphne go on a road trip in a Winnebago. They drive over the border into Canada only to learn that Daphne is not allowed to leave the U.S. because she does not have her green card yet.

Frasier and Niles try to collaborate on a book about sibling relationships but end up brawling while developing a case of writer's block.

Guest Caller: Christine Lahti as Laura

Frasier falls ill, and KACL restaurant critic Gil Chesterton (Edward Hibbert) tries to steal his time slot in his absence. Frasier begs Niles to take over to prevent this. When Niles unexpectedly runs the show with great success, a feverish Frasier begins to imagine plots against him, and decides to drag himself to the station no matter what. He locks Niles and Roz out of the studio and broadcasts in a state of delirium.

Guest Callers: Mary Tyler Moore as Marjorie; Patricia Hearst as Janice; Steve Lawrence as Howard; Eydie Gorme as Lois; Tommy Hilfiger as Robert; Garry Trudeau as Louis; Steve Young as Blake

Over their daily coffee, Frasier and Niles discuss life and happiness. For the first time, Niles acknowledges he may have feelings for Daphne. Frasier considers if he is happy with his new life in Seattle.