Frank McDonald may refer to:

• Frank McDonald (journalist) (born 1950), environment editor of The Irish Times
• Frank McDonald (director) (1899–1980), American film director
• Frank McDonald (footballer) (1899–1962), Australian footballer
• Frank B. McDonald (1925–2012), astrophysicist and creator of the Voyager probe
• Frank F. McDonald, former mayor of Evansville, Indiana
• Frank McDonald (American football), American football player
• Frank McDonald, Sr (1912–1997), mayor of Evansville, Indiana, 1960–1972
• Frank McDonald, II (born 1951), mayor of Evansville, Indiana, 1987–2000

• Francis McDonald (disambiguation)
• Franklin M. McDonald (1850–?), soldier
• Frank MacDonald (1896–2003), final surviving Tasmanian veteran of World War I
• Frankie MacDonald (born 1984), amateur weather man