Francisco Rodríguez may refer to:

• Frank Rodriguez (born 1972), pitcher for the Minnesota Twins and Seattle Mariners
• Francisco Rodríguez (Venezuelan pitcher) (born 1982), relief pitcher who is nicknamed "K-Rod"
• Francisco Rodríguez (Mexican pitcher) (born 1983), Mexican League, Tigres de Quintana Roo

• Francisco Rodríguez (boxer, born 1945) (1945–2024), Venezuelan boxer
• Francisco Rodriguez (boxer, born 1984) (1984–2009), American boxer
• Francisco Rodríguez Jr. (born 1993), Mexican boxer

• Francisco Rodríguez (cyclist, born 1906) (1906–?), Argentine cyclist
• Francisco Rodríguez (cyclist, born 1915) (1915–1998), Mexican cyclist
• Francisco Rodríguez Maldonado (born 1960), Colombian cyclist

• Francisco Javier Rodríguez (born 1981), Mexican footballer
• Francisco Rodríguez García (1934–2022), Spanish footballer
• Francisco (footballer, born 1978) (Francisco Javier Rodríguez, born 1978), Spanish footballer and manager
• Francisco Rodríguez (Swiss footballer) (born 1995), Swiss footballer
• Francisco Rodríguez (footballer, born 1993), Costa Rican footballer

• Francisco Rodríguez (rower) (born 1953), Cuban Olympic rower
• Francisco Rodríguez (Spanish judoka) (born 1957), Spanish Olympic judoka
• Francisco Rodríguez (tennis) (born 1976), Paraguayan tennis player
• Francisco Rodríguez (Puerto Rican judoka) (born 1970), Puerto Rican Olympic judoka
• Francisco José Rodríguez [Wikidata] (born 1980), Spanish volleyball player

• Francisco Rodríguez Adrados (1922–2020), Spanish Hellenist
• Francisco Rodríguez Pascual (1927–2007), Spanish humanist and anthropologist
• Francisco Rodríguez (President of Panama) (born 1938), in 1989
• Francisco Rodríguez Barrientos (born 1956), Costa Rican writer and sociologist
• Frankie A. Rodriguez (born 1996), American actor
• Francisco Rodríguez (economist), Venezuelan economist

• Frank Rodriguez, rock organist with Question Mark & the Mysterians
• Francisco Rodrigues (disambiguation)