Federici is a surname. Notable people with the surname include:

• Aldo Federici (1920–1988), Italian ice hockey player
• Adam Federici (born 1985), Australian footballer
• Andrea Federici (born 1997), Italian sprinter
• Anthony Federici (1940–2022), identified as a captain in the Genovese crime family
• Autumn Federici, American model, producer, and actress
• Camillo Federici (1749–1802), Italian actor and playwright
• Cesare Federici (c. 1530-1600/1603), Italian merchant and traveler
• Daniele Federici (born 1988), Italian footballer
• Daniel Paul "Danny" Federici (1950–2008), American musician
• Emanuele Federici (born 1978), Italian lightweight rower
• Frederick Federici (1850–1888), Italian-born British opera singer
• Giovanni Battista Federici (1615–1657), Roman Catholic prelate, Bishop of Sagone
• Italia Federici (born 1969), President of the Council of Republicans for Environmental Advocacy
• Nora Federici (1910–2001), Italian statistician
• Olivia Federici (born 1990), British swimmer
• Petrus Federici (1571–1613), Roman Catholic prelate, Bishop of Vulturara e Montecorvino
• Silvia Federici (born 1942), Italian American scholar, teacher, and activist
• William R. Federici (1917–2009), chief justice of the New Mexico Supreme Court