F15 or F-15 may refer to:

• Boeing F-15EX Eagle II, a development of the F-15E Strike Eagle
• McDonnell Douglas F-15 Eagle, an American-designed air-superiority fighter aircraft
• McDonnell Douglas F-15 STOL/MTD, a technology demonstrator based on the F-15 Eagle
• McDonnell Douglas F-15E Strike Eagle, an all weather strike fighter derived from the F-15 Eagle
• Northrop F-15 Reporter, a photo-reconnaissance variant of the P-61 Black Widow

• F-15 City Wars, a 1990 video game developed by American Video Entertainment on Nintendo
• F-15 Strike Eagle (video game), a 1984 video game
• F-15 Strike Eagle II, a 1989 video game
• F-15 Strike Eagle III, a 1993 video game
• Jane's F-15, a 1998 video game

• BMW X5 (F15), a mid-size luxury crossover SUV
• F15 and F15A, the two Ford 15-hundredweight versions of the World War II Canadian Military Pattern trucks
• February 15, 2003 anti-war protest
• Fluorine-15 (F-15 or ¹⁵F), an isotope of fluorine
• F15, a function key