Estrangement or Estranged may refer to:

• Family estrangement, the loss of a relationship between two or more family members
• Social alienation/isolation/estrangement, the loss of an individual's connection with society
• Estrangement effect, a performing arts concept coined by playwright Bertolt Brecht
• Self-estrangement, an idea by Karl Marx where a person is alienated from the products of labour
• Estrangement (album), released in August 2007 by the Ukrainian black metal band Drudkh
• Estrangement, an album by the German Gothic metal band Dreadful Shadows released in 1994
• "Estranged" (song), a power ballad and music video by the American hard rock band Guns N' Roses
• Estranged (band), a Malaysian alternative rock band
• Estranged (film), a 2006 20-minute short film directed by D. J. Matrundola