Escom or ESCOM may refer to:

• Escom AG, a defunct German computer corporation
• Escom LLC, Internet corporation best known as the former owner of the "sex.com" web domain
• ESCOM IPN, the Superior School of Computer Sciences of the National Polytechnic Institute of Mexico
• École supérieure de chimie organique et minérale, a French grande école for chemical engineering
• Eskom, South African electricity public utility, known as ESCOM until 1986
• Electricity Supply Commission of Malawi (ESCOM), Ltd, state-owned power producing company in Malawi
• European Society for the Cognitive Sciences of Music, non-profit learned society supporting research in the cognitive sciences of music