Eisenstadt is a German surname. Notable people with the surname include:

• Abraham Hirsch ben Jacob Eisenstadt of Byelostok (1812–1868), Russian rabbi
• Benjamin Eisenstadt (1906–1996), American inventor
• Debra Eisenstadt, American actress, writer, producer and director
• Harry Eisenstat, Major League baseball player
• Jill Eisenstadt (born 1963), American novelist
• Martin Eisenstadt, fictional "talking head" created by Dan Mirvish and Eitan Gorlin
• Meir Eisenstadt (1670–1744), Polish-German rabbi
• Mordechai Eisenstadt, Jewish Sabbatean
• Oona Eisenstadt, American religious studies professor
• Pauline Eisenstadt (1939–2024) , American politician
• Samuel Eisenstadt (1923–2010), research chairman at Value Line
• Shmuel Eisenstadt (1923–2010), Israeli sociologist