A duke is an aristocrat of very high rank.

Duke or The Duke may also refer to:

• Duke University, a private research university in Durham, North Carolina

• Duke, Missouri, an unincorporated community
• Duke (Kiseljak), a village in Bosnia and Herzegovina
• Duke Township, Harnett County, North Carolina
• Duke Township, Jackson County, Oklahoma – see List of Oklahoma townships
• (The) Duke City, a nickname for Albuquerque, New Mexico
• Duke Island (Alaska)
• La Duke Island, Nunavut, Canada

• Duke (nickname), a list of people
• Duke (given name), a list of people
• Duke (surname), including a list of people

• Bo, Luke, Daisy and Jesse Duke from the American television series
• Edmund Duke (StarCraft)
• Duke (G.I. Joe), from the G.I. Joe TV series, toy line and comic book series
• Uncle Duke, from Doonesbury
• Tony "Duke" Evers, in the Rocky films
• Duke Lavery, on the American soap opera General Hospital
• Duke, from KOF: Maximum Impact
• Duke, a narrow-gauge engine created by Rev W Awdry in The Railway Series and Thomas and Friends
• Duke of New York, aka "The Duke, A Number One", gang leader in Escape from New York
• Duke Nukem (character), the protagonist in over a dozen video games
• Duke, protagonist of the eponymous novel by Hal Ellson
• Duke, the family dog in the television series The Beverly Hillbillies
• Duke, an anthropomorphic dog with a southern accent in the comic Kelly & Duke
• Duke, a golden retriever who appears in commercials of Tennessee food producer Bush Brothers and Company (Bush's Baked Beans)
• Duke, the dog from Barnyard (film)
• Duke, a dog from The Secret Life of Pets
• Duke Forrest, from the film version of M*A*S*H
• Duke, a POW from the play and film Stalag 17
• Duke Oda, the player in the game Cyber Police ESWAT
• Duke Caboom, in Toy Story 4

• Duke Blue Devils, the athletic teams of Duke University
• The Duke (horse), a 19th-century racing champion
• "The Duke", the official nickname of the game ball used in the National Football League of American football

• TVNZ Duke, a New Zealand television channel
• Dukes Aerospace, a valve manufacturer and subsidiary of TransDigm Group
• Duke Energy, a producer of gas and electric services in the United States
• Dukes Hotel, a luxury hotel in London
• Duke Realty, a real estate investment trust in the United States
• Duke Records, a Memphis, Tennessee record label active from 1952 to 1973
• Duke Video, Motorsport DVD distributor based in the Isle of Man

• HMS Duke, various ships and a shore establishment of the Royal Navy
• Duke Field, a US Air Force airport in Florida
• Forward Operating Base Duke, a former US base in Iraq

• Beechcraft Duke, a twin-engined airplane developed by Beechcraft in the 1960s and manufactured until 1983
• Duke motorcycles, such as the KTM 690 Duke and the KTM 390 Duke
• The Duke, a short-lived 0-6-0 steam locomotive built in 1817 by George Stephenson for the Kilmarnock and Troon Railway
• GWR 3252 Class, or Duke Class, steam locomotive
• Duta–Ulu Klang Expressway (DUKE, E33), an expressway connecting various destinations located in Klang Valley, Malaysia

• Duke (mascot), the mascot of the Java programming language
• Duke butterflies, species of the brush-footed butterfly genera
• Duke, an electronic countermeasure (jammer) specifically designed for radio-controlled improvised explosive devices (RCIED)
• Xbox Controller, often nicknamed the Duke

• Duke (film), a 2019 crime drama film
• The Duke (TV series), 1954
• The Duke (miniseries), 1979
• The Duke (TV talk show), 2009, TV talk show for men by AXN Asia
• The Duke (1999 film), a 1999 Disney film
• The Duke (1998 film), a 1998 short film
• The Duke (2020 film), 2020 comedy-drama film

• Duke Ellington, American jazz pianist, composer and arranger
• Duke Special, Northern Irish singer-songwriter
• Duke (musician), a British vocalist/songwriter/composer/producer
• Rich Ward, guitarist of metal band Fozzy whose stage name is "The Duke"
• MC Duke, a British rapper

• Duke (album) (1980), by Genesis
• The Duke (Jørn Lande album) (2006), by Jørn Lande
• The Duke (Joe Jackson album) (2012)

• "The Duke", a 1957 jazz standard penned by Dave Brubeck
• "The Duke", a song by Blind Melon from Soup

• Duke: The Life and Times of John Wayne (1985)
• Duke (magazine), a defunct African-American men's magazine
• Duke, a 1949 novel by Hal Ellson

• Duke language, an Oceanic language
• Duke (Lombard), a type of political and military commander of the Lombards, 5th–8th centuries
• The Duke (board game)
• Duke, an old English paper size measuring 7×5.5 inches (178×140 mm)
• "The Duke", an episode of the TV series Adventure Time

• Dukes (disambiguation)
• Duke's, an Indian soft drink brand of Duke and Sons