Drenthe is a province of the Netherlands.

Drenthe may also refer to:

• Drenthe, Michigan, an unincorporated community in Zeeland Charter Township, Michigan
• Royston Drenthe (born 1987), Dutch footballer
• Drenthe University of Applied Sciences, a former Dutch university of applied sciences
• HNLMS Drenthe (D816), a destroyer of the Dutch navy
• A stage in the Saalian glaciation