Donald Brown may refer to:

• Donald F. Brown (archaeologist) (1908–2014), American archaeologist
• Donald Brown (anthropologist) (born 1934), American professor of anthropology
• Donald D. Brown (1931–2023), American biochemist and developmental biologist

• Donald Brown (musician) (born 1954), American jazz musician
• Don Brown (author) (born 1960), American novelist
• Don Brown (voice actor) (born 1964), Canadian voice actor
• Don Brown (children's author) (born 1949), American children's book author and illustrator

• Don Brown (American politician) (born 1954), commissioner to the Colorado Department of Agriculture, 2015–2018
• Don Brown (Australian politician) (born 1981), member of the Queensland Parliament
• Donald Ferguson Brown (1903–1959), Canadian politician, barrister and lawyer
• Donald Cameron Brown (1892–1963), Canadian politician in the Legislative Assembly of British Columbia

• Don Brown (American football coach) (born 1955), American college football coach
• Donald Brown (defensive back) (born 1963), American football defensive back
• Donald Brown (running back) (born 1987), American football running back
• Don Brown (running back) (1937–2013), American football player in the American Football League
• Donald Brown (Canadian football) (born 1985), American football defensive back in the Canadian Football League

• Don Brown (Australian footballer) (born 1953), Australian rules footballer
• Don Brown (runner), winner of the 1974 4 × 880 yard relay at the NCAA Division I Indoor Track and Field Championships

• Donald Forrester Brown (1890–1916), New Zealand Victoria Cross recipient
• Donald R. Brown (died 2009), first African American to attend dental school at the University of Missouri–Kansas City School of Dentistry
• Donald Brown (programmer), computer programmer and creator of the Eamon game series

• Don Browne (1943–2023), American television executive
• Don Browne (cricketer) (1892–1975), Barbadian cricketer