Diouf (French spelling in Senegal) or "Joof" (English spelling in The Gambia) is a Serer surname. Notable people with the name include:

• Abdou Diouf (born 1935), second president of Senegal, former Secretary-General of La Francophonie
• El Hadji Diouf (born 1981), Senegalese footballer
• Ibra Diouf, member of the Pan-African Parliament
• Jacques Diouf (1938–2019), Senegalese politician, Director-General Food and Agriculture Organization of the United Nations
• Mamadou Diouf (historian), Senegalese historian, professor at Columbia University
• Mame Biram Diouf (born 1987), Senegalese footballer
• Mame Tacko Diouf (born 1976), Senegalese hurdler
• Mouss Diouf (born 1964), French actor
• Ngalandou Diouf (1875–1941), Senegalese politician, first African elected official since the beginning of colonization
• Ndella Paye Diouf (born c. 1974), Senegal-born French Afro-feminist
• Papa Alioune Diouf (born 1989), Senegalese footballer
• Pape Diouf (1951–2020), President of Olympiques de Marseille
• Pape Paté Diouf (born 1986), Senegalese footballer
• Sylviane Diouf, French historian and writer
• Valentina Diouf (born 1993), Italian volleyball player
• Yehvann Diouf (born 1999), French footballer