Dione may refer to:

• 106 Dione, a large main belt asteroid
• Dione (moon), a moon of Saturn
• Helene (moon), a moon of Saturn sometimes referred to as "Dione B"

• Dione (Titaness), a Titaness in Greek mythology
• Dione (mythology), a name for various women in Greek mythology

• Dione (alga), a genus of red algae in the family Bangiaceae
• Dione (butterfly), a genus in the family Heliconiinae
• Pitar dione, the elegant venus clam

• Dione 98, a Spanish sailboat design

• Diketone (Dione), a molecule containing two ketone groups
• Ethylene dione (ethylenedione, ethene dione, or ethene 1,2-dione), a hypothetical chemical compound with the formula C₂O₂ (O=C=C=O)

• Dione Lucas (1909–1971), English chef and first female graduate of Le Cordon Bleu
• Dee Dee Sharp (born Dione LaRue, 1945), American R&B singer
• Dione Santos (born 1979), Brazilian footballer
• Dione Miguel Ribas (born 1993), Brazilian footballer
• Dione Taylor, Canadian jazz singer

• Dione (play), a 1720 work by the British writer John Gay

• Dee Bliss (Dione "Dee" Rebecchi), from the Australian soap opera Neighbours
• Thanos, a villain in Marvel Comics, was originally given the name by his mother

• Dione (Serer surname), a West African surname among the Serer people with no connection to the French "Dione"
• Rose Dione (1875–1936), French actress
• Aura Dione, Danish singer-songwriter

• Dione plc, a former UK-based point-of-sale equipment manufacturer, now part of VeriFone

• Deon, given name
• Deion (disambiguation)
• Dion (disambiguation)
• Dionne (disambiguation)
• Diode