Denebola may refer to:

• Denebola (β Leo, β Leonis, Beta Leonis), the third-brightest star in the constellation Leo
• Denebola brachycephala, an extinct whale

• SS Denebola, a German-built British cargo steam ship, 1899–1918
• SS Denebola (T-AKR-289), an Algol-class vehicle cargo ship currently maintained by the United States Maritime Administration
• USS Denebola (AD-12), was an Altair-class destroyer tender of the US Navy
• USS Denebola (AF-56), was a Denebola-class stores ship of the US Navy