Protein found in humans
Delta-like protein 1 is a protein that in humans is encoded by the DLL1 gene .[ 5]
Function DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis . It may play a role in cell-to-cell communication.[ 5]
Interactions Delta-like 1 has been shown to interact with NOTCH2 .[ 6] [ 7] [ 8]
References
^ a b c ENSG00000198719 GRCh38: Ensembl release 89: ENSG00000275555, ENSG00000198719 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014773 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: DLL1 delta-like 1 (Drosophila)" .^ Shimizu K, Chiba S, Saito T, Kumano K, Takahashi T, Hirai H (July 2001). "Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation" . J. Biol. Chem . 276 (28): 25753– 8. doi :10.1074/jbc.M103473200 PMID 11346656 . ^ Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S (July 1997). "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane" . Cell . 90 (2): 281– 91. doi :10.1016/s0092-8674(00)80336-0 PMID 9244302 . S2CID 16544864 . ^ Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (September 2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2" . Mol. Cell. Biol . 20 (18): 6913– 22. doi :10.1128/mcb.20.18.6913-6922.2000 . PMC 88767 PMID 10958687 .
Further reading
Watt FM (2002). "The stem cell compartment in human interfollicular epidermis". J. Dermatol. Sci . 28 (3): 173– 80. doi :10.1016/S0923-1811(02)00003-8 . PMID 11912004 . Lewis AK, Frantz GD, Carpenter DA, de Sauvage FJ, Gao WQ (1999). "Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear" . Mech. Dev . 78 (1– 2): 159– 63. doi :10.1016/S0925-4773(98)00165-8 PMID 9858718 . S2CID 9675950 . Mitsiadis TA, Hirsinger E, Lendahl U, Goridis C (1999). "Delta-notch signaling in odontogenesis: correlation with cytodifferentiation and evidence for feedback regulation" . Dev. Biol . 204 (2): 420– 31. doi :10.1006/dbio.1998.9092 PMID 9882480 . Gray GE, Mann RS, Mitsiadis E, Henrique D, Carcangiu ML, Banks A, Leiman J, Ward D, Ish-Horowitz D, Artavanis-Tsakonas S (1999). "Human Ligands of the Notch Receptor" . Am. J. Pathol . 154 (3): 785– 94. doi :10.1016/S0002-9440(10)65325-4 . PMC 1866435 PMID 10079256 . Beckers J, Clark A, Wünsch K, Hrabé De Angelis M, Gossler A (1999). "Expression of the mouse Delta1 gene during organogenesis and fetal development" . Mech. Dev . 84 (1– 2): 165– 8. doi :10.1016/S0925-4773(99)00065-9 PMID 10473134 . S2CID 15047523 . Morrison A, Hodgetts C, Gossler A, Hrabé de Angelis M, Lewis J (1999). "Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear" . Mech. Dev . 84 (1– 2): 169– 72. doi :10.1016/S0925-4773(99)00066-0 PMID 10473135 . S2CID 17955906 . Han W, Ye Q, Moore MA (2000). "A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells". Blood . 95 (5): 1616– 25. doi :10.1182/blood.V95.5.1616.005k31_1616_1625 . PMID 10688816 . Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2" . Mol. Cell. Biol . 20 (18): 6913– 22. doi :10.1128/MCB.20.18.6913-6922.2000 . PMC 88767 PMID 10958687 . Shimizu K, Chiba S, Saito T, Kumano K, Hirai H (2000). "Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors". Biochem. Biophys. Res. Commun . 276 (1): 385– 9. doi :10.1006/bbrc.2000.3469 . PMID 11006133 . Jaleco AC, Neves H, Hooijberg E, Gameiro P, Clode N, Haury M, Henrique D, Parreira L (2001). "Differential Effects of Notch Ligands Delta-1 and Jagged-1 in Human Lymphoid Differentiation" . J. Exp. Med . 194 (7): 991– 1002. doi :10.1084/jem.194.7.991 . PMC 2193482 PMID 11581320 . Shimizu K, Chiba S, Saito T, Takahashi T, Kumano K, Hamada Y, Hirai H (2002). "Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain" . EMBO J . 21 (3): 294– 302. doi :10.1093/emboj/21.3.294 . PMC 125840 PMID 11823422 . Panin VM, Shao L, Lei L, Moloney DJ, Irvine KD, Haltiwanger RS (2002). "Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe" . J. Biol. Chem . 277 (33): 29945– 52. doi :10.1074/jbc.M204445200 PMID 12036964 . Sakamoto K, Yamaguchi S, Ando R, Miyawaki A, Kabasawa Y, Takagi M, Li CL, Perbal B, Katsube K (2002). "The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway" . J. Biol. Chem . 277 (33): 29399– 405. doi :10.1074/jbc.M203727200 PMID 12050162 . Ohishi K, Varnum-Finney B, Bernstein ID (2002). "Delta-1 enhances marrow and thymus repopulating ability of human CD34+CD38– cord blood cells" . J. Clin. Invest . 110 (8): 1165– 74. doi :10.1172/JCI16167 . PMC 150801 PMID 12393852 . Karlström H, Beatus P, Dannaeus K, Chapman G, Lendahl U, Lundkvist J (2003). "A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 17119– 24. doi :10.1073/pnas.252624099 PMC 139279 PMID 12482954 . Tohda S, Murata-Ohsawa M, Sakano S, Nara N (2003). "Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines". Int. J. Oncol . 22 (5): 1073– 9. doi :10.3892/ijo.22.5.1073 . PMID 12684674 . Six E, Ndiaye D, Laabi Y, Brou C, Gupta-Rossi N, Israel A, Logeat F (2003). "The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase" . Proc. Natl. Acad. Sci. U.S.A . 100 (13): 7638– 43. Bibcode :2003PNAS..100.7638S . doi :10.1073/pnas.1230693100 PMC 164639 PMID 12794186 . LaVoie MJ, Selkoe DJ (2003). "The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments" . J. Biol. Chem . 278 (36): 34427– 37. doi :10.1074/jbc.M302659200 PMID 12826675 .
