De Palma or DePalma or De Palmas may refer to:

• Louie De Palma, a fictional character on the TV series Taxi. Role of the despotic dispatcher was played by Danny DeVito from 1978 to 1983
• De Palma (film), a documentary about film director Brian De Palma

• De Palmas, 2013 album by French singer Gérald de Palmas

• Anthony DePalma (1904–2005), American surgeon, humanitarian and teacher
• Dan DePalma (born 1989), American football player
• Gary DePalma (born 1976), American soccer player
• Gregory DePalma (1932–2009), American convicted criminal
• John DePalma (1885–1957), American auto racer
• Larry DePalma (born 1965), American ice hockey player
• Ralph DePalma (1882–1956), American auto racer

• Brian De Palma (born 1940), American film director and writer
• Esteban de Palma (born 1967), Argentinian volleyball player
• Joseph-François Charpentier de Cossigny de Palma (1736–1809), French engineer and explorer
• Jula de Palma (born 1932), Italian singer
• Michele De Palma (born 1973), Italian cancer researcher
• Piero de Palma (born 1916), Italian singer
• Rossy de Palma (born 1964), Spanish actress and model
• Samuel De Palma (1918–2002), American diplomat
• Fred De Palma (born 1989), Italian rapper

• Gérald de Palmas (born 1967) as Gérald Gardrinier, French singer
• Laurent de Palmas (born 1977), French footballer