David or Dave Murphy may refer to:

• David Murphy (Australian rules footballer) (born 1962), Australian rules footballer
• Dave Murphy (baseball) (David Francis Murphy, 1876–1940), American shortstop in Major League Baseball
• David Murphy (baseball) (David Matthew Murphy, born 1981), American baseball player
• David Murphy (cricketer) (born 1989), Scottish cricketer
• David Murphy (footballer, born 1917) (David Anthony Murphy, 1917–1944), English footballer
• David Murphy (footballer, born 1984) (David Paul Murphy), English footballer
• David Murphy (Laois Gaelic footballer) (born 1985), Gaelic footballer
• David Murphy (Wexford Gaelic footballer), Gaelic footballer

• David Murphy (CIA) (1921–2014), CIA station chief in Berlin, 1959–1961
• David Murphy (composer), Irish composer and harper
• David Lee Murphy (born 1959), American country music singer-songwriter
• David Murphy (Irish writer), Irish author
• Dave Murphy (politician) (David J. Murphy, born 1954), American businessman and politician in Wisconsin
• David Murphy, contestant on Survivor: Redemption Island (2011)