David Cohen may refer to:

• David Cohen (historian) (1882–1967), Dutch historian, Holocaust survivor
• David Cohen (rabbi) (1887–1972), Rabbi, talmudist, philosopher, and kabbalist
• David Cohen (physicist) (born 1930), M.I.T. physicist
• David B. Cohen (psychologist) (1941–2004), American psychology professor
• David K. Cohen (1934–2020), American education theorist
• David Mark Cohen (1952–1997), playwriting professor at the University of Texas at Austin
• David William Cohen (born 1943), professor of history and anthropology

• David Cohen (entrepreneur) (born 1968), American entrepreneur
• David Cohen (died 2002), founder of John's Bargain Store
• David Oliver Cohen (born 1980), American writer, actor and entrepreneur

• David Cohen (intelligence), New York City Police Department deputy commissioner, former CIA official
• David Cohen (politician) (1914–2005), American lawyer and Democratic politician in Philadelphia, PA
• David B. Cohen (mayor) (born 1947), American politician, mayor of Newton, Massachusetts
• David Jacob Cohen (died 1959), Indian politician
• David L. Cohen, American politician and US ambassador to Canada
• David S. Cohen (attorney) (born 1963), Deputy Director of the Central Intelligence Agency

• David Cohen (art critic) (born 1963), founding editor of artcritical.com, art critic, art historian, curator, and publisher
• Dave Cohen (sportscaster) (born 1951), American sportscaster and actor
• Dave Cohen (writer), writer for television, radio and the Huffington Post
• David Elliot Cohen (born 1955), American editor and publisher
• David Mark Cohen (1952–1997), playwriting professor at the University of Texas at Austin
• David Steven Cohen (born 1967), American TV writer (Strangers with Candy, Courage the Cowardly Dog)
• David X. Cohen (born 1966), American TV writer and producer (The Simpsons, Futurama)

• Dave Cohen (American football) (born 1966), American college football coach
• Dave Cohen (keyboardist) (born 1985), keyboardist
• David Bennett Cohen (born 1942), keyboardist and guitarist
• David Cohen (cellist) (born 1980), classical cellist from Belgium
• David Cohen (military) (1917–2020), member of the United States Army and school teacher
• David Cohen (diplomat), Israeli diplomat
• David Cohen (lawyer) (1946–2021), Canadian immigration lawyer
• David Cohen (jockey) (born 1984), American jockey

• Jack the Ripper suspects § David Cohen
• David Cohen Nassy (1612–1685), Portuguese converso and colonialist