DS2 may refer to:

• Dark Seed II, a 1995 adventure game
• Dark Souls II, a 2014 action role-playing video game
• Dead Space 2, a 2011 survival horror third-person shooter game
• Death Stranding 2, the upcoming sequel to Death Stranding
• Devil Summoner 2: Raidou Kuzunoha vs. King Abaddon, a 2008 action role-playing game in the Shin Megami Tensei series
• Devil Survivor 2, a 2011 strategy RPG in the Shin Megami Tensei series
• Dungeon Siege II, a 2005 action role-playing game
• Darksiders II, a 2012 action role-playing hack and slash game
• SimCity DS 2, 2008 city-building game for the Nintendo DS

• DS2 (album), a 2015 album by American rapper Future
• C-Net DS2, a 1986 bulletin board system (BBS) for the Commodore 64 microcomputer
• Datsun DS-2, a 1951 car in the Datsun DS series
• DS-2, a type of Soviet satellite including Kosmos 1
• Deep Space 2, a probe of NASA's New Millennium Program
• Design of Systems on Silicon, Powerline communication's chipset developer

• DSS (disambiguation)
• DSDS
• Nintendo 2DS