DDB may refer to:

• Dangerous Drugs Board, an agency of the Government of the Philippines
• DDB Worldwide, an advertising agency
• Digital Dictionary of Buddhism
• Dogue de Bordeaux, breed of dog
• Dortmund Data Bank, a factual data bank for thermophysical and thermodynamic data
• DDB, Bitmap graphics or Digidesign Database File, in the Alphabetical list of filename extensions
• DDB, distributed database, is a database in which storage devices are not all attached to a common processor.
• Deutsche Digitale Bibliothek
• D&D Beyond

• Daryl Bonilla (born 1975), American actor, comedian and professional wrestler known as "Dangerous" Daryl Bonilla
• Daniel de Bourg, English pop singer