Clifton High School may refer to:

• Clifton High School, Bristol – Clifton, Bristol

• Clifton High School (Clifton, New Jersey) – Clifton, New Jersey
• Clifton High School (Clifton, Arizona) – Clifton, Arizona (closed September 2010)
• Clifton Central High School – Clifton, Illinois
• Lake Clifton Eastern High School – Baltimore, Maryland
• Clifton High School (Clifton, Texas) – Clifton, Texas
• Clifton Forge High School – a former high school in Clifton Forge, Virginia