Clean sweep may refer to:

• Clean sweep (naval), a naval expression meaning a successful mission
• Clean Sweep (film), a 1918 silent film comedy short
• Clean Sweep, a 1974 video game by Ramtek Corporation.
• Clean Sweep (video game), a 1982 video game for the Vectrex
• Clean Sweep (TV series), a 2023 Irish television police drama series
• Operation Clean Sweep, a 2004 coalition counter-insurgency operation in Iraq
• A Clean Sweep, a 1958 British comedy film
• Clean-Sweep, a fictional character in the G.I. Joe universe
• Clean Sweep, a Hardy Boys novel
• Quarterdeck CleanSweep, a software utility for Microsoft Windows used to uninstall applications
• Podium sweep or clean sweep, when one team wins all available medals in a single sporting event