Charles Upton may refer to:

• Charles W. Upton (born c. 1943), American economist
• Charles H. Upton (1812–1877), politician and statesman from Massachusetts and Virginia
• Charles Upton (poet) (born 1948), American poet, Sufi and metaphysician
• Charles L. Upton (1870–1936), American physician and college football coach
• Charles Upton Lowe (1921-2012), for whom Oculocerebrorenal syndrome or Lowe syndrome was named
• Charles Upton, High Sheriff of Derbyshire in 1809