Champagne is a French surname. Notable people with the surname include:

• Albert Champagne (1866–1937), Canadian rancher, hotel-owner and political figure
• Andre Champagne (born 1943), Canadian ice hockey player
• Andrée Champagne (1939–2020), Canadian actress, pianist and politician
• Charles Champagne (disambiguation), multiple people
• Claude Champagne (1891–1965), Canadian composer
• Claudette Champagne, Canadian social activist
• Connie Champagne (born 1959 as Kelly Kay Brock), American singer, songwriter and actor
• David B. Champagne (1932–1952), American navy corporal and Medal of Honor recipient
• Frances Champagne, Canadian neuroscientist
• François-Philippe Champagne (born 1970), Canadian politician
• Jean-François Champagne (1751–1813), French scholar
• Jérôme Champagne (born 1958), French diplomat
• Keith Champagne (born 1970), American comic artist
• Kenneth Champagne, Canadian judge
• Louis Champagne, Canadian actor
• Louis Champagne, Canadian talk radio personality
• Louis Napoléon Champagne (1860–1911), Canadian lawyer, judge and politician
• Michel Champagne (born 1956), Canadian politician and businessman
• Napoléon Champagne (1861–1925), Canadian politician
• Nereo Champagne (born 1985), Argentine football goalkeeper
• Noëlla Champagne (born 1944), Canadian politician
• Peter B. Champagne (1845–1891), American politician
• Ronald Champagne (born 1942), American higher education administrator
• Salvatore Champagne, American operatic tenor

• Champagnie, surname