Science in the broadest sense refers to any system of knowledge attained by verifiable means and in a narrower sense to a system of acquiring knowledge based on empiricism, experimentation, and methodological naturalism, as well as to the organized body of knowledge humans have gained by such research. Scientists maintain that scientific investigation must adhere to the scientific method, a process for evaluating empirical knowledge that explains observable events in nature as results of natural causes, rejecting supernatural notions.

Islam has its own worldview system including beliefs about "ultimate reality, epistemology, ontology, ethics, purpose, etc. Muslims believe that the Qur'an is the literal word and the final revelation of God for the guidance of humankind.