Castle House may refer to:

• Castle House, Bridgwater, an 1851 house in Somerset, England
• Castle House, Dedham, housing the Sir Alfred Munnings Art Museum in Essex, England
• Castle House, Laugharne, a Georgian Mansion in Carmarthenshire, Wales
• Castle House, Usk, a listed building in Monmouthshire, Wales
• Castle House building, Ludlow Castle, Shropshire, England
• Castle House, a former Sheffield Co-operative Society store in South Yorkshire, England
• Castle House, now the site of Strata SE1, London, England
• Castle House, now the site of Old College, Aberystwyth, Ceredigion, Wales
• Castle House, or Bailieborough Castle, County Cavan, Ireland
• Castle House, Dunoon, Argyll and Bute, Scotland.
• Castle House School, Newport, Shropshire, England

• The Mystery at Castle House, a 1982 Australian film for children
• Sir George Sutton, 1st Baronet, of Castle House, Banstead, Surrey, a Sutton baronet