Casali is an Italian surname. Notable people with the surname include:

• Andrea Casali (1705–1784), Italian painter
• Arianna Farfaletti Casali (born 1976), former Italian-born Swiss female pole vaulter
• Charles Casali (1923–2014), Swiss footballer
• Curt Casali (born 1988), American baseball player
• Giovanni Battista Casali (1715–1792), Italian musician
• Giovanni Battista Casali del Drago (1838–1908), Italian cardinal
• Giovanni di Casali (c. 1320–after 1374), Italian mathematician and theologian
• Giovanni Battista Casali (1715–1792), Italian musician
• Giulio Casali (born 1932), Sammarinese professional football player and manager
• Italo Casali (1940–2019), Sammarinese former sports shooter
• Kim Casali (1941–1997), New Zealand cartoonist
• Casali brothers, Dario and Milo Casali
• Libero Casali (born 1939), Sammarinese former sports shooter
• Paolo Casali. Italian-American academic and immunologist
• Stefano Casali (born 1962), Sammarinese racewalker
• Tino Casali (born 1995), Austrian football player

• Casale (disambiguation)
• Casalis (sometimes plural casali), a medieval settlement type