Casale is an Italian surname. Notable people with the surname include:

• Gerald Casale (born 1948), American musician
• Giovanni Casale (born 1980), Italian judoka
• Giuseppe Casale (1923–2023), Italian bishop
• Ignacio Casale (born 1987), Chilean four-wheeler motorcycle rider
• Jean Casale (1893–1923), French World War I flying ace credited with thirteen aerial victories
• Jerry Casale (1933–2019), American Major League Baseball pitcher
• Luigi Casale (1882–1927), industrial chemist
• Marcela Casale (born 1986), Italian female field hockey player for the Italian national team
• Mark Casale (born 1962), former American football player
• Nathalie Alonso Casale (born 1970), Dutch filmmaker
• Nicolò Casale (born 1998), Italian football player
• Pamela Casale-Telford (née Casale; born 1963), American former professional tennis player
• Primo Casale (1904–1981), Italian-born Venezuelan conductor, composer, and violinist
• Rita Casale (born 1968), Italian-German educationalist, philosopher and university lecturer
• Roger Casale (born 1960), former Labour Member of Parliament for Wimbledon
• Rossana Casale (born 1959), Italian singer
• Stefano Casale (born 1971), Italian footballer
• Suzanne Casale Melone (born 1979), birthname of the American freestyle/pop singer Li Suzy;
• Ubertino da Casale (1259–1329), Italian theologian