Cardinale is a surname. Notable people with the surname include:

• Claudia Cardinale (born 1938), Tunisian-born Italian actress
• Gerald Cardinale (1934–2021), American politician
• Igino Eugenio Cardinale (1916–1983), Italian Roman Catholic archbishop and diplomat
• Lindsey Cardinale (born 1985), American singer
• Marco Cardinale (born 1973), Italian sports scientist and administrator
• Salvatore Cardinale (born 1948), Italian politician
• Tina Cardinale-Beauchemin (born 1966), American athlete

• Cardenal
• Cardinal (disambiguation)
• Cardinali (disambiguation)