CUSA may refer to:

• Kues, town in Germany
  • Nicholas of Cusa (1401–1464), German philosopher, theologian, jurist, and astronomer
• Carleton University Students' Association, Carleton University in Ottawa, Ontario, Canada
• Colleges and Universities Sports Association, a collegiate athletic conference in the Philippines
• Conference USA, a collegiate athletic conference in the United States
• Council of Unions of South Africa, a former South African trade union federation
• Canada and the United States; see List of country groupings § C
• Cavitron Ultrasonic Surgical Aspirator