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CNOT8

CNOT8
Identifiers
AliasesCNOT8, CAF1, CALIF, Caf1b, POP2, hCAF1, CCR4-NOT transcription complex subunit 8
External IDsOMIM: 603731; MGI: 1916375; HomoloGene: 48304; GeneCards: CNOT8; OMA:CNOT8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

9337

69125

Ensembl

ENSG00000155508

ENSMUSG00000020515

UniProt

Q9UFF9

Q9D8X5

RefSeq (mRNA)

NM_026949
NM_001356477
NM_001363084
NM_001363085
NM_001363086

RefSeq (protein)

NP_081225
NP_001343406
NP_001350013
NP_001350014
NP_001350015

Location (UCSC)Chr 5: 154.86 – 154.88 MbChr 11: 57.99 – 58.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CCR4-NOT transcription complex subunit 8 is a protein that in humans is encoded by the CNOT8 gene.[5][6][7] It is a subunit of the CCR4-Not deadenylase complex.

Interactions

CNOT8 has been shown to interact with BTG2,[8] BTG1,[8][9] CNOT1[6][10] and CNOT3.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000155508 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020515 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fidler C, Wainscoat JS, Boultwood J (May 1999). "The human POP2 gene: identification, sequencing, and mapping to the critical region of the 5q- syndrome". Genomics. 56 (1): 134–6. doi:10.1006/geno.1998.5687. PMID 10036195.
  6. ^ a b c Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (March 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.
  7. ^ "Entrez Gene: CNOT8 CCR4-NOT transcription complex, subunit 8".
  8. ^ a b Prévôt D, Morel AP, Voeltzel T, Rostan MC, Rimokh R, Magaud JP, Corbo L (March 2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". J. Biol. Chem. 276 (13): 9640–8. doi:10.1074/jbc.M008201200. PMID 11136725.
  9. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  10. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading


Quelle: http://en.wikipedia.org/wiki/CNOT8