Protein-coding gene in the species Homo sapiens
Cyclin-dependent kinases regulatory subunit 2 is a protein that in humans is encoded by the CKS2 gene .[ 5] [ 6] [ 7]
CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function . The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells , which reflects specialized role for the encoded protein.[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000123975 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062248 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Richardson HE, Stueland CS, Thomas J, Russell P, Reed SI (Dec 1990). "Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe" . Genes Dev . 4 (8): 1332– 44. doi :10.1101/gad.4.8.1332 PMID 2227411 . ^ Demetrick DJ, Zhang H, Beach DH (Sep 1996). "Chromosomal mapping of the human genes CKS1 to 8q21 and CKS2 to 9q22". Cytogenet Cell Genet . 73 (3): 250– 4. doi :10.1159/000134349 . PMID 8697818 . ^ a b "Entrez Gene: CKS2 CDC28 protein kinase regulatory subunit 2" .
External links
Further reading
Parge HE, Arvai AS, Murtari DJ, et al. (1993). "Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control". Science . 262 (5132): 387– 95. Bibcode :1993Sci...262..387P . doi :10.1126/science.8211159 . PMID 8211159 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Le XF, Lammayot A, Gold D, et al. (2005). "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling" . J. Biol. Chem . 280 (3): 2092– 104. doi :10.1074/jbc.M403080200 PMID 15504738 . Gorr IH, Boos D, Stemmann O (2005). "Mutual inhibition of separase and Cdk1 by two-step complex formation" . Mol. Cell . 19 (1): 135– 41. doi :10.1016/j.molcel.2005.05.022 PMID 15989971 . Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell . 122 (6): 957– 68. doi :10.1016/j.cell.2005.08.029 . hdl :11858/00-001M-0000-0010-8592-0 PMID 16169070 . S2CID 8235923 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173– 8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Rother K, Dengl M, Lorenz J, et al. (2007). "Gene expression of cyclin-dependent kinase subunit Cks2 is repressed by the tumor suppressor p53 but not by the related proteins p63 or p73" . FEBS Lett . 581 (6): 1166– 72. doi :10.1016/j.febslet.2007.02.028 PMID 17336302 . S2CID 6953397 . Bertheau P, Turpin E, Rickman DS, et al. (2007). "Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen" . PLOS Med . 4 (3): e90. doi :10.1371/journal.pmed.0040090 PMC 1831731 PMID 17388661 .
