Mammalian protein found in Homo sapiens
Chemokine (C-C motif) ligand 8 (CCL8), also known as monocyte chemoattractant protein 2 (MCP2), is a protein that in humans is encoded by the CCL8 gene .[ 3] [ 4]
CCL8 is a small cytokine belonging to the CC chemokine family. The CCL8 protein is produced as a precursor containing 109 amino acids , which is cleaved to produce mature CCL8 containing 75 amino acids. The gene for CCL8 is encoded by 3 exons and is located within a large cluster of CC chemokines on chromosome 17q 11.2 in humans.[ 4] [ 5] chemotactic for and activates many different immune cells, including mast cells , eosinophils and basophils , (that are implicated in allergic responses), and monocytes , T cells , and NK cells that are involved in the inflammatory response.[ 6] [ 7] chemokine receptors . These receptors include CCR1 , CCR2B , CCR3 and CCR5 .[ 7] [ 8]
CCL8 is a CC chemokine that utilizes multiple cellular receptors to attract and activate human leukocytes. CCL8 is a potent inhibitor of HIV1 by virtue of its high-affinity binding to the receptor CCR5, one of the major co-receptors for HIV1.[ 9] [ 10] [ 11]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000108700 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: chemokine (C-C motif) ligand 8" .^ a b Van Coillie E, Fiten P, Nomiyama H, Sakaki Y, Miura R, Yoshie O, Van Damme J, Opdenakker G (March 1997). "The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2". Genomics . 40 (2): 323–31. doi :10.1006/geno.1996.4594 . PMID 9119400 . ^ Van Damme J, Proost P, Lenaerts JP, Opdenakker G (July 1992). "Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family" . J. Exp. Med . 176 (1): 59–65. doi :10.1084/jem.176.1.59 . PMC 2119277 PMID 1613466 . ^ Proost P, Wuyts A, Van Damme J (January 1996). "Human monocyte chemotactic proteins-2 and -3: structural and functional comparison with MCP-1". J. Leukoc. Biol . 59 (1): 67–74. doi :10.1002/jlb.59.1.67 . PMID 8558070 . S2CID 30445255 . ^ a b Gong W, Howard OM, Turpin JA, Grimm MC, Ueda H, Gray PW, Raport CJ, Oppenheim JJ, Wang JM (February 1998). "Monocyte chemotactic protein-2 activates CCR5 and blocks CD4/CCR5-mediated HIV-1 entry/replication" . J. Biol. Chem . 273 (8): 4289–92. doi :10.1074/jbc.273.8.4289 PMID 9468473 . ^ Ge B, Li J, Wei Z, Sun T, Song Y, Khan NU (2017). "Functional expression of CCL8 and its interaction with chemokine receptor CCR3" . BMC Immunol . 18 (1): 54. doi :10.1186/s12865-017-0237-5 PMC 5745793 PMID 29281969 . ^ PDB : 1ESR Blaszczyk J, Coillie EV, Proost P, Damme JV, Opdenakker G, Bujacz GD, Wang JM, Ji X (November 2000). "Complete crystal structure of monocyte chemotactic protein-2, a CC chemokine that interacts with multiple receptors". Biochemistry . 39 (46): 14075–81. doi :10.1021/bi0009340 . PMID 11087354 . ^ Farmaki E, Chatzistamou I, Kaza V, Kiaris H (2016). "A CCL8 gradient drives breast cancer cell dissemination" . Oncogene . 35 (49): 6309–6318. doi :10.1038/onc.2016.161 . PMC 5112152 PMID 27181207 . ^ Hamilton SA, Tower CL, Jones RL (2013). "Identification of chemokines associated with the recruitment of decidual leukocytes in human labour: potential novel targets for preterm labour" . PLOS ONE . 8 (2): e56946. Bibcode :2013PLoSO...856946H . doi :10.1371/journal.pone.0056946 PMC 3579936 PMID 23451115 .
External links
Further reading
Struyf S, Proost P, Vandercappellen J, et al. (2009). "Synergistic up-regulation of MCP-2/CCL8 activity is counteracted by chemokine cleavage, limiting its inflammatory and anti-tumoral effects". Eur. J. Immunol . 39 (3): 843–57. doi :10.1002/eji.200838660 . PMID 19224633 . S2CID 41872921 . Rom S, Rom I, Passiatore G, et al. (2010). "CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cells" . FASEB J . 24 (7): 2292–300. doi :10.1096/fj.09-143503 PMC 2887261 PMID 20181935 . Menon R, Pearce B, Velez DR, et al. (2009). "Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants" . Reprod. Biol. Endocrinol . 7 : 62. doi :10.1186/1477-7827-7-62 PMC 2714850 PMID 19527514 . Segat L, Brandão LA, Guimarães RL, et al. (2010). "Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment" . Vaccine . 28 (10): 2201–6. doi :10.1016/j.vaccine.2009.12.056 PMID 20056178 . Rajaraman P, Brenner AV, Butler MA, et al. (2009). "Common variation in genes related to innate immunity and risk of adult glioma" . Cancer Epidemiol. Biomarkers Prev . 18 (5): 1651–8. doi :10.1158/1055-9965.EPI-08-1041 . PMC 2771723 PMID 19423540 . Han S, Lan Q, Park AK, et al. (2010). "Polymorphisms in innate immunity genes and risk of childhood leukemia" . Hum. Immunol . 71 (7): 727–30. doi :10.1016/j.humimm.2010.04.004 . PMC 2967770 PMID 20438785 . Velez DR, Fortunato SJ, Thorsen P, et al. (2008). "Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants" . PLOS ONE . 3 (9): e3283. Bibcode :2008PLoSO...3.3283V . doi :10.1371/journal.pone.0003283 PMC 2553267 PMID 18818748 . Villa C, Venturelli E, Fenoglio C, et al. (2009). "CCL8/MCP-2 association analysis in patients with Alzheimer's disease and frontotemporal lobar degeneration". J. Neurol . 256 (8): 1379–81. doi :10.1007/s00415-009-5138-y . PMID 19415413 . S2CID 3147096 . Siezen CL, Bont L, Hodemaekers HM, et al. (2009). "Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes" . Pediatr. Infect. Dis. J . 28 (4): 333–5. doi :10.1097/INF.0b013e31818e2aa9 PMID 19258923 . S2CID 25601837 . Vyshkina T, Sylvester A, Sadiq S, et al. (2008). "CCL genes in multiple sclerosis and systemic lupus erythematosus" . J. Neuroimmunol . 200 (1–2): 145–52. doi :10.1016/j.jneuroim.2008.05.016 . PMC 5301077 PMID 18602166 . Ruhwald M, Bodmer T, Maier C, et al. (2008). "Evaluating the potential of IP-10 and MCP-2 as biomarkers for the diagnosis of tuberculosis" . Eur. Respir. J . 32 (6): 1607–15. doi :10.1183/09031936.00055508 PMID 18684849 . Skibola CF, Bracci PM, Halperin E, et al. (2008). "Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma" . PLOS ONE . 3 (7): e2816. Bibcode :2008PLoSO...3.2816S . doi :10.1371/journal.pone.0002816 PMC 2474696 PMID 18636124 . Ockinger J, Stridh P, Beyeen AD, et al. (2010). "Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis" . Genes Immun . 11 (2): 142–54. doi :10.1038/gene.2009.82 PMID 19865101 . Rajaraman P, Brenner AV, Neta G, et al. (2010). "Risk of meningioma and common variation in genes related to innate immunity" . Cancer Epidemiol. Biomarkers Prev . 19 (5): 1356–61. doi :10.1158/1055-9965.EPI-09-1151 . PMC 3169167 PMID 20406964 . Velez DR, Fortunato S, Thorsen P, et al. (2009). "Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants" . Am. J. Obstet. Gynecol . 200 (2): 209.e1–27. doi :10.1016/j.ajog.2008.08.051 . PMC 4829203 PMID 19019335 . Dean RA, Cox JH, Bellac CL, et al. (2008). "Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx" . Blood . 112 (8): 3455–64. doi :10.1182/blood-2007-12-129080 PMID 18660381 . Hori T, Naishiro Y, Sohma H, et al. (2008). "CCL8 is a potential molecular candidate for the diagnosis of graft-versus-host disease" . Blood . 111 (8): 4403–12. doi :10.1182/blood-2007-06-097287 . PMC 2288733 PMID 18256320 . Schuurhof A, Bont L, Siezen CL, et al. (2010). "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls". Pediatr. Pulmonol . 45 (6): 608–13. doi :10.1002/ppul.21229 . PMID 20503287 . S2CID 24678182 .
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