Protein-coding gene in humans
Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene .[ 5] [ 6]
Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin -dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.[ 6]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000134072 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030272 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Haribabu B, Hook SS, Selbert MA, Goldstein EG, Tomhave ED, Edelman AM, Snyderman R, Means AR (Sep 1995). "Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase" . EMBO J . 14 (15): 3679–86. doi :10.1002/j.1460-2075.1995.tb00037.x . PMC 394442 PMID 7641687 . ^ a b "Entrez Gene: CAMK1 calcium/calmodulin-dependent protein kinase I" .
Further reading
Bredt DS, Ferris CD, Snyder SH (1992). "Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites" . J. Biol. Chem . 267 (16): 10976–81. doi :10.1016/S0021-9258(19)49862-1 PMID 1375933 . Yokokura H, Picciotto MR, Nairn AC, Hidaka H (1995). "The regulatory region of calcium/calmodulin-dependent protein kinase I contains closely associated autoinhibitory and calmodulin-binding domains" . J. Biol. Chem . 270 (40): 23851–9. doi :10.1074/jbc.270.40.23851 PMID 7559563 . Liu F, Thompson MA, Wagner S, et al. (1993). "Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation" . J. Biol. Chem . 268 (9): 6714–20. doi :10.1016/S0021-9258(18)53308-1 PMID 8384217 . Chin D, Winkler KE, Means AR (1998). "Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I" . J. Biol. Chem . 272 (50): 31235–40. doi :10.1074/jbc.272.50.31235 PMID 9395448 . Hsu LS, Tsou AP, Chi CW, et al. (1998). "Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase". J. Biomed. Sci . 5 (2): 141–9. doi :10.1007/bf02258368 . PMID 9662074 . Matsushita M, Nairn AC (1998). "Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase" . J. Biol. Chem . 273 (34): 21473–81. doi :10.1074/jbc.273.34.21473 PMID 9705275 . Anderson KA, Means RL, Huang QH, et al. (1998). "Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta" . J. Biol. Chem . 273 (48): 31880–9. doi :10.1074/jbc.273.48.31880 PMID 9822657 . Matsushita M, Nairn AC (1999). "Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase" . J. Biol. Chem . 274 (15): 10086–93. doi :10.1074/jbc.274.15.10086 PMID 10187789 . Hayashi Y, Nishio M, Naito Y, et al. (1999). "Regulation of neuronal nitric-oxide synthase by calmodulin kinases" . J. Biol. Chem . 274 (29): 20597–602. doi :10.1074/jbc.274.29.20597 PMID 10400690 . Hosaka M, Hammer RE, Südhof TC (1999). "A phospho-switch controls the dynamic association of synapsins with synaptic vesicles" . Neuron . 24 (2): 377–87. doi :10.1016/S0896-6273(00)80851-X PMID 10571231 . S2CID 14103027 . Komeima K, Hayashi Y, Naito Y, Watanabe Y (2000). "Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells" . J. Biol. Chem . 275 (36): 28139–43. doi :10.1074/jbc.M003198200 PMID 10874031 . McKinsey TA, Zhang CL, Lu J, Olson EN (2000). "Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation" . Nature . 408 (6808): 106–11. Bibcode :2000Natur.408..106M . doi :10.1038/35040593 . PMC 4459600 PMID 11081517 . McKinsey TA, Zhang CL, Olson EN (2001). "Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5" . Proc. Natl. Acad. Sci. U.S.A . 97 (26): 14400–5. Bibcode :2000PNAS...9714400M . doi :10.1073/pnas.260501497 PMC 18930 PMID 11114197 . Hsu LS, Chen GD, Lee LS, et al. (2001). "Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity" . J. Biol. Chem . 276 (33): 31113–23. doi :10.1074/jbc.M011720200 PMID 11395482 . Condon JC, Pezzi V, Drummond BM, et al. (2002). "Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase" . Endocrinology . 143 (9): 3651–7. doi :10.1210/en.2001-211359 PMID 12193581 . Sakurada K, Kato H, Nagumo H, et al. (2003). "Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin" . J. Biol. Chem . 277 (47): 45473–9. doi :10.1074/jbc.M206673200 PMID 12237306 . Clapperton JA, Martin SR, Smerdon SJ, et al. (2003). "Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: studies of the kinase activation mechanism". Biochemistry . 41 (50): 14669–79. doi :10.1021/bi026660t . PMID 12475216 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med . 9 (2): 191–7. doi :10.1038/nm822 . PMID 12539042 . S2CID 26145639 .
External links
Activity Regulation Classification Kinetics Types
