Brian McDonald or MacDonald may refer to:

• Brian McDonald (Australian footballer) (born 1927), Australian rules footballer
• Brian Macdonald (choreographer) (1928–2014), Canadian dancer, choreographer and director
• Brian McDonald (Gaelic footballer) (born 1980)
• Brian McDonald (ice hockey) (born 1945), former ice hockey centre
• Brian Macdonald (politician), Canadian politician
• Brian MacDonald (sailor) (born 1943), Canadian Paralympic sailor
• Brian McDonald (screenwriter) (born 1965), American screenwriter
• Brian MacDonald, of the singing duo The MacDonald Brothers